Pharmaceutical Excipients Icodextrin Is The Main Components Of Peritoneal Dialysis Fluid
Product Introduction
Icodextrin is made of glucose molecules connected by α-1,4-glycosidic bonds and α-1,6-glycosidic bonds. It contains more α-1,6-glycosidic bonds, which makes it have better solubility and fluidity. When digested in the body, it can produce oligosaccharides, promote the intestinal absorption of water and form a gel-like substance, playing a certain nutritional support role.
Product Application
1. Application in peritoneal dialysis
As an osmotic agent, icodextrin is mainly used in peritoneal dialysis (PD), especially continuous ambulatory peritoneal dialysis (CAPD) for patients with chronic renal failure. It forms colloidal osmotic pressure through high molecular weight dextrin, prolongs the ultrafiltration time of dialysate in the peritoneal cavity, improves dehydration efficiency, and helps remove excess water and metabolic waste in the body.
2. Comparison with traditional glucose dialysis fluid
The molecular weight of icodextrin peritoneal dialysis fluid is large and not easily absorbed by the peritoneum, so it can maintain the osmotic gradient for a long time and improve the ultrafiltration effect. In contrast, traditional peritoneal dialysis fluid with glucose as the osmotic agent has a small molecular weight and is easily absorbed, making it difficult to maintain the osmotic gradient for a long time, which may lead to a decrease in ultrafiltration and changes in the peritoneal structure and function.
3. Biocompatibility and safety
Icodextrin peritoneal dialysis fluid does not contain glucose and is suitable for diabetic patients to reduce the impact of blood sugar. Studies have shown that the use of icodextrin peritoneal dialysis fluid can reduce the risk of congestive heart failure, atrial fibrillation and stroke.
In addition, icodextrin peritoneal dialysis fluid also has high biocompatibility, reducing irritation and damage to the peritoneum.
4. Indications
Icodextrin peritoneal dialysis fluid is suitable for patients with peritoneal ultrafiltration failure, high transport or high average transport, diabetes, and patients with excessive volume load and insufficient ultrafiltration.
5. Other medical applications
In addition to its application in peritoneal dialysis, icodextrin is also used to assist in improving the discomfort caused by abnormal liver function, such as loss of appetite, nausea and vomiting, fatigue, etc. It can also relieve liver inflammation in patients with chronic hepatitis B, enhance the body's resistance to disease, and inhibit the replication of hepatitis B virus.
In addition, icodextrin also has the functions of supplementing nutrition, promoting digestion, regulating immune function, promoting wound healing, and maintaining fluid balance.
Product Packaging
Company Profile
ZIBO WEYES NEW MATERIALS CO.,LTD is a series of high-tech enterprises integrating scientific research, production and sales, specializing in research and production of cyclodextrin and derivatives, food and cosmetic additives, nutritional supplements and other plant extracts.The company has built an auxiliary material production workshop in line with cGMP, equipped with advanced inspection and testing instruments and equipment, constantly studying the inclusion technology, and providing comprehensive cyclodextrin application technology solutions and OEM services.
Company Certificate
Logistics
By air, by express(DHL,FedEx,UPS.etc), by sea or other modes of transportation.
We will discuss and provide samples according to customer needs.
FAQ
Q1. Can I have a sample order for Icodextrin?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable.
Q2. What about the lead time?
A: 3-5 days for Sample preparing ,8-10 working days for mass production.
Q3. Do you have any MOQ limit for Icodextrin order?
A: Low MOQ, 1kg for sample checking is available.
Q4. How do you ship the goods and how long does it take to arrive?
A: Ship by DHL, UPS, FedEx. It takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5.What services do you have?
A:We provide excellent after-sales service; we offer productcustomization services.
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