Dehydration Active Pharmaceutical Ingredient Icodextrin For Peritoneal Dialysis

Maximize Dehydration Efficiency with Active Pharmaceutical Ingredient Icodextrin for Peritoneal Dialysis

Product Introduction

Icodextrin is made of glucose molecules connected by α-1,4-glycosidic bonds and α-1,6-glycosidic bonds. It contains more α-1,6-glycosidic bonds, which makes it have better solubility and fluidity. When digested in the body, it can produce oligosaccharides, promote the intestinal absorption of water and form a gel-like substance, playing a certain nutritional support role.

Product Application

1. Application in Peritoneal Dialysis

As an osmotic agent, icodextrin is primarily used in peritoneal dialysis (PD), particularly continuous ambulatory peritoneal dialysis (CAPD) for chronic renal failure patients. By leveraging its high-molecular-weight dextrin structure, it generates colloidal osmotic pressure, prolonging the ultrafiltration duration of dialysate in the peritoneal cavity. This enhances dehydration efficiency and aids in removing excess body water and metabolic waste.

2. Comparison with Traditional Glucose Dialysate

Icodextrin-based peritoneal dialysate features a large molecular weight, making it poorly absorbable by the peritoneum. This allows it to maintain osmotic gradients over extended periods, optimizing ultrafiltration effects. In contrast, traditional glucose-based dialysates—with their small molecular size and high absorbability—struggle to sustain osmotic gradients, potentially leading to reduced ultrafiltration and peritoneal structural/functional alterations.

3. Biocompatibility and Safety

Free of glucose, icodextrin peritoneal dialysate is suitable for diabetic patients, minimizing blood sugar impacts. Studies indicate its use reduces risks of congestive heart failure, atrial fibrillation, and stroke. Additionally, its high biocompatibility reduces peritoneal irritation and damage.

4. Indications

Icodextrin peritoneal dialysate is indicated for:

Patients with peritoneal ultrafiltration failure
High-transport or high-average-transport peritoneal characteristics
Diabetes mellitus
Excessive volume overload and inadequate ultrafiltration

5. Other Medical Applications

Beyond peritoneal dialysis, icodextrin:

Alleviates discomfort from liver dysfunction (e.g., anorexia, nausea, vomiting, fatigue)
Reduces liver inflammation in chronic hepatitis B patients, enhances disease resistance, and inhibits hepatitis B virus replication
Provides nutritional support, promotes digestion, regulates immune function, accelerates wound healing, and maintains fluid balance

Product Packaging

Company Profile

ZIBO WEYES NEW MATERIALS CO.,LTD is a series of high-tech enterprises integrating scientific research, production and sales, specializing in research and production of cyclodextrin and derivatives, food and cosmetic additives, nutritional supplements and other plant extracts.The company has built an auxiliary material production workshop in line with cGMP, equipped with advanced inspection and testing instruments and equipment, constantly studying the inclusion technology, and providing comprehensive cyclodextrin application technology solutions and OEM services.

Company Certificate

Logistics

By air, by express(DHL,FedEx,UPS.etc), by sea or other modes of transportation.

We will discuss and provide samples according to customer needs.

FAQ

Q1. Can I have a sample order for Icodextrin?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable.

Q2. What about the lead time?
A: 3-5 days for Sample preparing ,8-10 working days for mass production.

Q3. Do you have any MOQ limit for Icodextrin order?
A: Low MOQ, 1kg for sample checking is available.

Q4. How do you ship the goods and how long does it take to arrive?
A: Ship by DHL, UPS, FedEx. It takes 3-5 days to arrive. Airline and sea shipping also optional.

Q5.What services do you have?
A:We provide excellent after-sales service; we offer productcustomization services.